Interestingly, trNK cells from unmanipulated mice display markers associated with cNK cell activation, such as CD69, in contrast to cNK cells which do not express CD69 until activated (Karlhofer and Yokoyama, 1991; Wang et al., 2000).
Our analysis indicated that in this particular data set, markers associated with mouse BMI through either additivity or imprinting can be effectively detected, and the functions of the genes or QTLs harboring these markers supported our discovery on the marker-trait association.
J147 reduced cognitive deficits in old SAMP8 mice, while restoring multiple molecular markers associated with human AD, vascular pathology, impaired synaptic function, and inflammation to those approaching the young phenotype.
However, lesions from TIMP-2 −/− Apoe −/− mice had higher levels of markers associated with plaque vulnerability, including increased macrophage: vascular smooth muscle cell ratios, larger necrotic core areas, reduced collagen contents, increased macrophage proliferation, and apoptosis frequencies, compared with TIMP-1 −/−Apoe −/− and controls.
By breeding hundreds or thousands of mice, they can look for genetic markers associated with traits like obesity or high cholesterol.
The cells were stained with FITC-, PE- or PE-cy5-conjugated mAbs against surface markers associated with DC maturation, these include: anti-mouse CD11c, anti-mouse CD40, anti-mouse CD80 (Cedarlane Laboratories, Mississauga, ON, Canada).
Since the data used here was generated for a series of studies on mice diabetes, it was not surprising that markers associated with diabetes-related QTL were detected.
Finally, we validate that DMF administration to mice with EAE results in upregulation of microglia markers associated with neuroprotection and mitigates deleterious alterations in synaptic transmission.
The cells were stained with FITC-conjugated mAbs against surface markers associated with DC maturation (anti-mouse CD11c, I-A, CD40, and CD86; Cedarlane, Hornby, ON, Canada).
To confirm that colonies exhibiting ESC-like morphology expressed proteins associated with pluripotent cells, sheep iPSC colonies were stained for a number of surface and intracellular markers associated with undifferentiation in human and mouse cells.
