Sentence examples for mouse mammary models from inspiring English sources

Interestingly, the specific response of these three transgenic mouse mammary models to bexarotene treatment varies with the genetic background assessed.

However, in this study, targeted deletion of MMP9 in mouse mammary models of breast cancer such as MMTV-Neu and MMTV-Wnt-1 resulted in increased tumorigenesis.

We present in Figure 4 a protein-protein interaction network associating the common core of non-random bexarotene modulated genes across transgenic mouse mammary models.

We previously analyzed the chemopreventive effectiveness of a highly selective RXR agonist, the rexinoid bexarotene (LGD1069) in three different transgenic mouse mammary models [ 6, 7].

Analysis of gene expression changes induced by bexarotene in mammary gland revealed that 89 genes were dysregulated among the three transgenic mouse mammary models.

The protein-protein interaction network associating genes of the three transgenic mouse mammary models was generated using the database STRING ('Search Tool for the Retrieval of Interacting Genes/Proteins') [ 17].

The Wnt1-induced mouse mammary model is significant to our understanding of tumor stem cells, for at least two reasons.

MSC inhibits TM6 cell growth at the hyperplastic and tumor stages in the mouse mammary model.

Moreover, overexpression of a stable transcriptionally active β-catenin in a mouse mammary model induced multiple aggressive mammary adenocarci-nomas [ 6].

These studies are based on the use of highly metastatic mouse mammary model, the FVB/N-TgN MMTV-PyVT 634Mul mouse (Guy et al, 1992).

In vivo, MMP-3 is centrally involved in mammary gland development [ 61], and has been demonstrated to promote tumour initiation and formation in the tetracycline-regulated mouse mammary model [ 62, 63].