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Mouse macrophages lacking TLR13 failed to induce IL-1β and other cytokines in response to ISR23.
On the other hand, mouse macrophages lacking RhoB, or human PC3 prostate cancer cells depleted of RhoB by RNAi, migrate faster than control cells.
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IL-1β, IL-12, and TNF-α levels are decreased in LPS-stimulated mice with macrophages lacking HIF-2α, while IL-10 levels are increased.
The gene for Ifnphi1, which belongs to the type I interferon group (Hamming et al., 2011), was dependent on MyD88 for its induction during S. typhimurium infection, as was described for mouse IFN1 when macrophages lacking MYD88 were stimulated with LPS (Hirotani et al., 2005).
At the same time, the mouse granuloma macrophages lacked bactericidal activity against BCG-mycobacteria that were located in the vacuoles and cytoplasm of the host cells with engulfed lymphocytes and thrombocytes.
Out et al. observed a moderate increase in atherosclerosis, whereas two other independent groups reported that macrophages lacking ABCG1 decrease atherosclerosis in hyperlipidemic Ldlr /– mice.
► Increased cholesterol efflux from macrophages lacking DGAT1.
Direct co-culture of WT macrophages from HFD-fed mice with 3T3L1 adipocytes gave rise to increased activation of JNK and impaired insulin signalling in adipocytes and this was significantly abrogated in adipocytes incubated with macrophages lacking CD36.
Macrophage recruitment to the stroma surrounding TEBs, TEB formation and adolescent ductal outgrowth are severely impaired in myelosuppressed (gamma-irradiated) mice and mice lacking macrophage-colony-stimulating factor-1 (CSF-1) or its receptor, but are rescued by bone marrow transplantation in irradiated mice and by exogenous CSF-1 or a mammary-targeted CSF-1 transgene in CSF-1-null mice.
In contrast to A0 macrophages, however, H0 macrophages lack TG accumulation.
On the other hand, Winnicka et al. [ 14] reported that lack of CD13 in mouse macrophages did not affect Fc γR-mediated phagocytosis or scavenger receptor-mediated endocytosis.
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