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Our study showed that implantation of syngeneic BrdU-labeled BMSCs resulted in a lower uptake of BrdU by mouse macrophages compared to xenogenic hBMSCs.
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Histologically, atherosclerotic lesions of Fpr2−/− mice contained fewer macrophages compared with lesions in wild-type mice, which is in line with the chemotactic effects of different peptide ligands for FPR2/ALX, and that signalling through this receptor mediates integrin activation in monocytes.
We found significant increases in 7-hydroxydocosahexaenoic acid (d5-7-HDHA), d5-14-HDHA and5-17-HDHAHas(Fig 4A) as well as in SPMs d5-Resolvin D1 (RvD1; Fig 4B) production by R-848-treated mouse macrophages when compared to cells exposed to vehicle alone.
Notably, at both 24 and 48 h post-exposure, mice that had been exposed to mosquito feeding prior to WNV inoculation tended to have fewer skin macrophages compared to mice inoculated with WNV alone.
The analysis of differential cell types in the BALF showed that mice challenged with dead A. fumigatus conidia had significantly more macrophages compared to naïve mice at day 3 after third fungal challenge).
However, studies using bone marrow chimaeric mice to genetically manipulate peripheral macrophages compared with CNS-resident microglia have demonstrated that these two types of macrophages are not functionally identical (reviewed in Carson et al., 2006).
All carotid lesions of irradiated mice given control chow showed erythrocyte/iron-containing macrophages compared with 44% of the unirradiated mice s (p = 0.01) (Table 2).
The Ad-IKKβKO mice displayed increased F4/80+CD11c+ macrophages and F4/80+CD11c+CD206+ macrophages compared with adipose tissue of WT mice on a HFD.
Our data reveal that hBD-3 overexpressing cells, derived from the tumorigenic HEK293 cell line, form xenograft tumors in nude mice with massive infiltration of host macrophages compared with those generated from parent cells.
As expected, retinas from oxygen-treated C57BL/6 mice displayed a significant increase in the number of infiltrating F4/80+ macrophages compared to retinas from normoxic control mice (Figure 3B).
Furthermore those that remained had virtually no interaction with macrophages compared to that seen in control mice (Figure 7B).
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