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We functionally identify those genes whose suppression promotes tumorigenesis in a mouse lymphoma model.
The mouse lymphoma assay (MLA) is the most widely used in vitro mammalian gene mutation assay.
Agarwal, M. L. et al. Photodynamic therapy induces rapid cell death by apoptosis in L5178Y mouse lymphoma cells.
Cosette, J. et al. Bioluminescence-Based Tumor Quantification Method for Monitoring Tumor Progression and Treatment Effects in Mouse Lymphoma Models.
The approach worked startlingly well in laboratory mice with transplanted mouse lymphoma tumors in two sites on their bodies.
A statistical method to evaluate data from the mouse lymphoma L5178Y/tk assay (MLA) using microwell method is proposed.
No mutagenicity was observed with the Neostiks in the Ames test or in the mouse lymphoma assay.
It detects various mutation events involving the thymidine kinase (Tk) gene in L5178Y/Tk+/− −3.7.2C mouse lymphoma cells.
Using a mouse lymphoma model to distinguish driver from passenger lesions, we functionally validated nine tumour suppressors of B-cell non-Hodgkin's lymphoma.
EL4 is a line of highly aggressive mouse lymphoma cells that induces rapid and lethal ascites in mice as described previously31.
Correspondingly, supplementation of exogenous recombinant IL-7 markedly amplified and sustained polyfunctional CD4+ effector cells, resulting in improved therapeutic outcome in a mouse lymphoma model.
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