An adult mouse lung consists of about 2.3 Mio.
In the mouse lung, ILC2s are defined as Lin−CD90+ICOS+CD25+ST2+CD127+.
In the optically cleared mouse lung, we observed branching major blood vessels in transplanted mouse lung (Fig. S7A).
Mouse lung was monitored by small animal micro-CT before transplantation to verify lung damage.
In control experiment, we found that the transplanted SOX9+ progenitors cannot incorporate into non-injured healthy mouse lung or porcine pancreatic elastase-injured mouse lung (data not shown).
In contrast to mouse lung development, our knowledge about WNT signaling in human lung development remains sparse.
Then the mice were sacrificed, and the mRNA levels of indicated genes in mouse lung were detected by RT-PCR.
(D ) RBM47 expression in normal mouse lung.
In the lungs, Ripk3-/ mice preserved better integrity of microscopic structure with reduced apoptosis, and decreased levels of IL-6, macrophage inflammatory protein (MIP -2 and keratinocyte-derived cheMIP -2 (KC), compandd to WT.
Adams has a photograph of those mouse lungs above his desk.
