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Additionally, Foxa2 directly binds to the Gata4 locus in adult mouse liver, supporting a role for Foxa2 as a direct upstream regulator of Gata4 expression (Wederell et al., 2008).
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We split the Dlk1-Dio3 megacluster into 13 subclusters and stably expressed each in a mouse liver tumor cell line (Supporting Fig. 3A; Supporting Table 3).
Nonetheless, the loss of electron absorbance observed in CTMP knockout mice liver mitochondria further supports the involvement of CTMP in the maintenance of inner mitochondrial membrane integrity.
This observation supports the view that a mouse liver tumor response is not an appropriate end point for human risk assessment.
Our defined mouse liver medium (ERFHNic [ Huch et al., 2013b]) supported the growth of human liver cells only for 2 3 weeks.
A similar amount of HCS (21 119) and supporting reads (3 681 375) is listed in APADB for mouse liver.
This conclusion is supported by recent in vitro studies in mouse liver cell lines (22).
ChIP-seq data for CTCF and DNase-DGF in mouse liver were collected by the Ren and Stamatoyannopoulous labs respectively for the modENCODE consortium, supported by the National Human Genome Research Institute.
Supporting evidence of hepcidin regulation by the Nrf2-Keap1 also also come from microarray analyses of mouse liver RNA.
This conclusion is also supported by the observation that chow diet with addition of mature MIR168a significantly enhanced the levels of mouse liver MIR168a (Figure 6N) and plasma LDL-cholesterol (Figure 6Q) but decreased mouse liver LDLRAP1 protein level (Figure 6O and 6P).
In vivo studies on the mouse liver with low-dose-rate irradiation showed results indicating a distinction between high- and low-dose exposures [9], which support the results found by Taki et al. in the mouse kidney [10].
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