Several liver end points were significantly elevated in the Blokkersdijk mice: liver weight, relative liver weight, peroxisomal beta-oxidation activity, microsomal lipid peroxidation level, and mitochondrial fraction protein content.
Efficiency was determined using pooled cDNAs, and the level of α9 expression was calculated as normalised to EF1A1 expression and relative to mouse liver samples as calibrator.
Also, few dozens of nuclear mt genes in mice are hypomethylated in the liver relative to the cerebrum [ 11].
o, p'-DDT elicits phenobarbital-type activities in the mouse liver, characterized by the increase in relative liver weight or induction of Cyp2b10, Cyp3a11 and GST mRNA levels [ 27, 28].
The harvested tissues from the diltiazem-treated D409H mice showed a 1.2-fold increase in GCase activity in the liver relative to those in untreated mice (Fig. 4).
The As absorption edge from mouse liver is displaced to lower energy by about 1.5 eV relative to the As III) standard, using the inflection point as a reference, and significantly more relative to the arsenate [As V)] standard.
Furthermore, Nishimori et al. and Li et al. showed that when administered to mice together, 70-nm silica nanoparticles and some drugs increased the toxicity on the liver relative to that observed when either is administered alone in mice [20, 21].
The relative levels of each SHMT2 isoform was determined in mouse liver and kidney by western blot analyses (Figure 7).
In summary, increased cell size results in the relative reduction of mitochondrial metabolism and lipid biosynthesis in mouse liver.
We also noted that HNF4A3 expression was higher in human liver relative to rodent liver (17% v/s 0% in mouse and 1% total HNF4A expression in rat; p = 0.027).
