The mouse liver eQTL network is a connected graph of 408 eQTL nodes, 4086 gene nodes, and 11,458 edges.
HNF1β also plays an important role in the regulatory network in mouse liver cells.
A second major set of altered gene functional networks in aging mouse liver involves the interconnected cellular proliferation and death networks.
Interestingly, the network corresponding to WT mouse liver sample contains almost double the number of edges (2073) as compared to the number of edges (1055) in the ob/ob mouse liver sample network.
We used two data sets, a yeast dataset [31], [32] and a mouse liver dataset [22], to construct the eQTL networks.
Further, when the transcriptional regulatory networks were compared between human and mouse liver, they were found to differ dramatically [ 50].
We analyzed the eQTL networks constructed from a yeast dataset and a mouse liver dataset and found 65 and 98 modules respectively.
Here we analyzed the expression QTL (eQTL) networks derived from expression genetic data of yeast and mouse liver and found 65 and 98 modules respectively.
Hence, gene-expression profiling, pathway, network and gene-set enrichment analysis and immunohistochemistry were carried out on mouse liver after 0, 124 24 and 72 hours of fasting.
For instance, one research group obtains livers of mice that have undergone certain treatments and distributes slices of these livers to different collaborators within the Virtual Liver Network.
