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All mouse lines show abnormal tissue formation caused by the disrupted cell cell junctions.
It is noteworthy that all three mouse lines show similar pathologies in mesenchymal tissues, with the skeletal system, being predominantly affected.
The phenotypes observed in Megf8 L1775P and Megf8 − mouse lines show a striking resemblance to those observed in mice lacking BMP4 signaling (Table 1).
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Compared with the wild-type mouse, they found that 15 mutant mouse lines showed significantly decreased pulmonary metastatic foci and 8 mutant mouse lines increased.
There are few naturally occurring or engineered mouse lines showing as severe a skeletal myopathy as observed with ectopic expression of CAR in the homozygotes.
During conditioning both mouse lines showed increased fear responses as assessed by freezing behaviour.
Another preferential site of expression was the developing CNS: 3/5 mouse lines showed transient fiZ expression in the spinal cord and hindbrain at E11.5 to E12.5 (fig. 4C D).
Interestingly, 3/5 mouse lines showed expression in the newborn (fig. 5A, D, G) and adult brain (fig. 5B, C, E, F, H, I).
The precise analysis of BAC transgenic mouse lines shows that 100% of the MSNs express D1R or D2R or in a minority of cases both.
Again, all three mouse lines showed a significant variation over the day regarding the time spent exploring the cage (Friedman-tests: N = 12 for each line, Chir2 = 135.5 149.5, df = 23, all p<0.001; see Fig. 3).
Regarding the diurnal rhythm of glucocorticoid secretion, all three mouse lines showed a significant variation of CM concentrations over the 24-hour light-dark cycle (Friedman-tests: N = 12 for each line, Chir2 = 100.9 110.5, df = 12, all p<0.001; see Fig. 4).
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CEO of Professional Science Editing for Scientists @ prosciediting.com