Several mouse lines provide evidences for the proposal of "handshake" model in the internal capsule, where pioneer TC and CT axons encounter and interact to guide each other.
In addition, these mouse lines provide a foundation for future efforts aimed at deciphering the role of NGF in the treatment of glaucoma.
"The tools and mouse lines provided by this project allow the neuroscience community to perform detailed studies of each gene," says Laura Mamounas, the GEN-SAT project officer at the NINDS.
Immunosuppression induced by inhibiting S1PL activity has potential application in the treatment of a variety of autoimmune and inflammatory diseases, and the humanized S1PL mouse line provides an attractive model for studying small molecule inhibitors of the human enzyme.
Therefore, this mouse line provides a unique tumor model that broadly extends the possibilities to study potential multistep-processes involved in tumorigenesis in vivo, with high relevance to human hematological malignancy.
The Tc1 mouse line provides a suitable model for studying the underlying genetic causes of the DS AVSD cardiac phenotype.
A Cre driver mouse line provides a 'genetic switch' in a cell type that, through site-specific recombination between loxP recognition sites, can turn on or off the various molecular probes that allow these cells to be analyzed by all the above modern techniques in their native circuit in vivo.
