Sentence examples for mouse lines overexpressing from inspiring English sources

Here, we used two mouse lines overexpressing human A53T-SNCA and studied striatal dysfunction in the absence of neurodegeneration to understand early disease mechanisms.

The two mouse lines overexpressing A53T-SNCA, PrPmtA and PrPmtB, were compared with their background strain FVB/N as WT controls while the SNCA-deficient (KO) mouse line was compared with its background strain 129sv/ev as WT control.

To characterize the role of eIF-5A2 in vivo, we generated transgenic mouse lines overexpressing human eIF-5A2 ubiquitously.

Consistent with these findings, electrophysiological studies of different mouse lines overexpressing mutant PS1 showed significantly enhanced LTP at hippocampal synapses [ 5, 7, 55, 144, 173, 211, 221].

The recently established transgenic mouse lines overexpressing the naturally occurring K8 G61C and R340H variants will likely offer valuable insights in this respect (Ku and Omary 2006; Zhou et al., unpublished data).

In mouse lines overexpressing long-chain acyl-CoA synthetase in the heart (17), LV dysfunction occurs in parallel with an over-stimulation of oxidation and ROS and ceramide formation, although cardiac steatosis and hypertrophy are concomitantly present.

A transgenic mouse line overexpressing mitofilin was generated and mice injected intraperitoneally with streptozotocin using a multi low-dose approach.

A transgenic mouse line overexpressing the CaMKIIδc exhibited severe alterations of Ca2+ cycling and dilated heart failure [ 15, 34].

In this particular instance, our first choices would have been the use of a mouse line overexpressing a bovine transgene in combination with 1 that overexpresses a caprine transgene.

In order to provide additional evidence for a causal role of Zfp69 and to investigate the mechanism of its diabetogenic potency, we generated a transgenic mouse line overexpressing the gene on the B6 and NZO × B6 background, and studied glucose homeostasis and fat distribution.

Four independent transgenic mice lines overexpressing Wt, D606G, deletion of amino acid 605 607 (Delocated7) located in seventh β-propeller in the second domain, and at positions 601 640 (Del601–640), a deletion of the entire seventh β-propeller of same domain, were developed independently in B7D2F1 (DBA/2J+C57BL/6J) mouse strain (Fig.  1A).