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Several genetically engineered mouse lines have high incidences of these tumors.
To date, six transgenic mouse lines have been developed that target Cre to the RPE under the control of various gene promoters.
In addition to the gabrb3 gene deficient mouse line, gene deficient mouse lines have been created for other genes found in the 15q11 13 region including the ubiquitin-protein ligase E3A (ube3andand gamma-aminobutyric acid (GABA) A receptor, alpha 5 (genes5) genes.
Recently, mouse lines have been produced with targeted disruptions of various genes in the renin-angiotensin system, and studies of these animals have provided new insights into a well-studied physiological system.
By using a noninfectious HIV-1 DNA construct lacking the gag and pol genes, three transgenic mouse lines have been generated that develop a syndrome remarkably similar to the human disease.
HoxB7-Cre and Catnbexon3flox mouse lines have previously been described [19], [20].
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We found that all three mouse lines had significantly elevated bone mass in the appendicular skeleton and in the cranium.
In preclinical literature, the use of inbred mouse lines has allowed for the examination of ethanol effects across vulnerable and resistant phenotypes.
This phenomenon of failed beta-galactosidase activity in the ZEG mouse lines has been previously described: beta-galactosidase activity was absent in the liver and lungs of ZEG lines, but robust GFP fluorescence was observed following cre-mediated recombination[5].
Indeed, our technique should prove of considerable advantage for the analysis of gene expression of specific cell populations in the many existing transgenic mouse lines having genes tagged by fluorescent protein expression.
Our finding that all of the muscle-specific p38 MKO mouse lines had normal IIb-to-IIa fiber-type transformation may also suggest that PGC-1α function is at least not required for contractile adaptation.
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