Sentence examples for mouse lines harboring from inspiring English sources

Finally, split-Cre is also compatible with the increasing number of mouse lines harboring LoxP-flanked genes for conditional knock-out studies [6].

Unfortunately, this strategy is limited to fate mapping rather than the generation of knockout mice by the need for special reporter alleles which is not compatible with the numerous mouse lines harboring LoxP-flanked genes.

Transgenic mouse lines harboring the Tet- BRAF* elements were crossed with another transgenic mouse lines expressing the reverse tetracycline transactivator under the control of the tyrosinase promoter/enhancer elements (designated Tyr-rtTA) to produce cohorts of single (Tet-BRAF*) and double (designated iBRAF*, Tet-BRAF*; Tyr-rtTA) transgenic animals.

In general, for obtaining several Tg mouse lines harboring a specific transgene, it typically requires approximately 200 or more eggs.

We recently generated a mouse line harboring a conditional Myog allele (Myogflox) and a Cre-ER transgene that allows us to investigate the role of myogenin in the adult mouse [8].

By gene replacement strategy they also generated a mouse line harboring the D320K mutation in the Npn1 locus.

For this purpose, we generated a transgenic mouse line harboring CAG-loxP-STOP-loxP-Six1 cassette (CAG-lxl-Six1) and crossed it with P0-Cre mice.

TgTSPY9 transgenic mouse line, harboring multiple copies of 8.2 kb genomic fragment of human TSPY gene on its Y-chromosome, was originally constructed by Drs. Stephanie Schubert and Jorge Schmidtke [ 43].

In this study, we generated a mouse line harboring a point mutation in the endogenous Nrp1 locus that selectively abolishes VEGF-NRP1 binding (Nrp1 VEGF− ).

DOI: http://dx.doi.org/10.7554/eLife.03720.006 A gene replacement strategy was implemented to generate a mouse line harboring the Nrp1 D320K mutation in the endogenous Nrp1 locus, delineated as Nrp1 VEGF −.

For example, generation and breeding of another mouse line harboring Disc1 L100P, which can be accomplished by in vitro fertilization by the cryopreserved sperm of the G1 progeny owned by RIKEN BRC, may facilitate full elucidation of a relationship between genetic components, including Disc1 L100P mutation per se, and behavioral phenotypes, related with schizophrenia in this mouse line.