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However, most of these mouse lines do not show the frank LC degeneration that occurs in human AD.
Yet no perfect animal model for PD exists; most transgenic mouse lines do not show damage to the nigrostriatal system, but rather have subtle changes.
Although the fRIM1/POMC-cre+ mice and fRIM1/KA-cre+ mice show some overlapping cre expression, the two mouse lines do not share any behavioral abnormalities.
In summary, with the exception of L7/Pcp2 Cre ::Tsc1 flox/+ mice, these mouse lines do not show gross alterations in granule or PC density.
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Both mouse lines did not carry the described mutation.
Consistent with these observations it has previously been suggested that inhibitory fibers in this Thy1-ChR2 mouse line do not express ChR2 (Gradinaru et al., 2009).
Further studies are needed, however, to assess whether the PPI deficits are limited to the advanced phase of the pathology or whether the R6/1 mouse line does not model this HD-like symptom.
We found the Cre penetrance of this mouse line did not enable the labeling of all gastric SST-producing cells, in accordance with a previous study reporting 80% efficiency of Cre-dependent rexpressionpressinn in the pancreas (40).
The Fmr1-mouse line does not recapitulate all of the main core and secondary ASD symptoms, but still can be useful to elucidate the neurobiological mechanisms underlying specific ASD-like endophenotypes.
Also, understanding the consequences of decreased VAChT expression is made easier now by the new mouse lines that do not show confounding peripheral phenotypes.
To control for the specificity of this response, we showed that CD4+ and CD8+ splenocytes isolated from non immunized mice (grey lines) or LT R192G) treated mice (black lines) did not proliferate in response to either RSV or N SRS (Fig. 5A).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com