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The two new mouse lines described here expand the repertoire of genetically engineered mice available for controlled in vivo recombination and cell labeling using the Cre-lox system.
The new mutant mouse lines described here were used to address the following questions: i) is PiT1 essential for embryo development?
The two new mouse lines described here add to the growing list of genetically engineered mice available for controlled in vivo recombination and cell labeling using the Cre-lox system.
We used this tandem Ret CreERT ; Rosa Tdt allele to specifically label RA mechanoreceptors in different mutant mouse lines described in the text.
Due to the complex breeding schemes required for the generation of some of the mouse lines described, it was not always possible to obtain littermates with all possible control genotypes.
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The development of the Nf1 GRD/+ mouse line described here will allow researchers to determine the necessity of GRD function across the spectrum of developmental and tumor phenotypes observed in mouse models of neurofibromatosis.
In addition to the results obtained with the K14-PTHrP transgenic mouse line described earlier, a recently published study illustrates that basal keratin promoters can be used to address important questions concerning the mammary gland.
The R26PR mouse line described here is a powerful model for the spatial and temporal control of Prdm14 misexpression, which can be used to investigate the role of PRDM14 in multiple cancer types.
One study examined slices from two different mouse models – the first was the DISC1Tm1Kara mouse line described above (Koike et al., 2006), and the second was the line expressing a truncated human DISC1 construct in a forebrain-specific manner, developed by Pletnikov et al. (2008).
Considering the number of human ES cell lines that have been established so far, the intensive testing of a number of these lines for erythroid potential may allow the establishment of human erythroid cell lines similar to the mouse erythroid cell lines described here.
The establishment of individual Rnd3 KO and ROCK1 KO mouse lines were described previously.
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