Sentence examples for mouse lines deficient from inspiring English sources

Mouse lines deficient for atxn2 develop marked hyperphagia and obesity raising the possibility that loss-of-function mutations in the ATXN2 gene may be related to energy balance in humans.

Mouse lines deficient for Sac1 are cell lethal, whereas Sac1 downregulation in mammalian cell cultures results in disorganization of Golgi membranes and mitotic spindles (21).

Mouse lines deficient in FGFR4 (FGFR4−/−) or KLB (KLB−/−) were prepared as described [ 8], and liver tissues were collected for gene expression analyses at one year of age.

To study the role of Sei1, we have generated a mouse line deficient for this gene.

We have generated a mouse line deficient in CgB and studied the effects of this mutation at the molecular, cellular and systemic level.

In addition, a double knockout mouse line, deficient in P1d and desmin has been generated (Konieczny et al. 2008), and a muscle-restricted conditional plectin knockout line lacking dystrophin in addition to plectin has recently become available (Raith et al. 2013).

Figure  2 A demonstrates that we successfully generated a mice line deficient in platelet IR (IRflox/flox Pf4-Cre+), whereas the levels of key signalling components such as IGF1R, IRS-1, IRS-2, IRS-3, and Akt were comparable to WT platelets.

Both human and mouse cell lines deficient in the CS proteins indeed display enhanced sensitivity to agents that produce oxidative DNA damage (Dianov et al. 1999; Tuo et al. 2003; de Waard et al. 2004; Gorgels et al. 2007; D'Errico et al. 2007; Stevnsner et al. 2008).

In addition to the gabrb3 gene deficient mouse line, gene deficient mouse lines have been created for other genes found in the 15q11 13 region including the ubiquitin-protein ligase E3A (ube3andand gamma-aminobutyric acid (GABA) A receptor, alpha 5 (genes5) genes.

PyVmT/Usp18 knockout (KO) and PyVmT/Usp18 wild-type (WT) mice were generated by crossing the PyVmT and Usp18 deficient mouse lines.

H2AX located in chromatin domains around IR-induced DSBs is phosphorylated by ATM and DNA-PK, but the levels of phosphorylation detected by different research groups in mouse and human cell lines deficient either in ATM or DNA-PK significantly differ.