Three independent mouse lines containing this construct were utilized in this study.
To capitalize on the separable nature of FP reporters we have generated transgenic mouse lines containing different FP spectral variants allowing us to cross two or more mouse lines together to further define bone cell populations [ 6].
Chimeric males derived by injecting ES cells into blastocysts were used to establish mouse lines containing the desired point mutations as well as the floxed NeoR cassette used for ES cell selection.
By crossing a mouse line containing floxed alleles for Dicer, a critical protein for the generation of mature miRNAs, with a Rx-cre transgenic mouse line, we conditionally deleted Dicer in all the cells of the retina and ventral hypothalamus from the initiation of their development.
The CCSP-rtTA mouse line contains the Clara cell secretory protein (CCSP or CC10) promoter which drives expression of the reverse tetracycline transactivating protein (rtTA) in lung Clara cells, alveolar Type II pneumocytes and some other non-ciliated bronchial and bronchiolar epithelial cells [23], [39].
However, despite this limitation, when the sEGFP7 mouse line containing a Cre-activated enhanced green fluorescent protein (EGFP) was infected with the Cre expressing virus, sites of latent and persistent virus infection could be identified within B cells and macrophages of the lymphoid system on the basis of EGFP expression.
The D2 mouse line contains an in-frame deletion within the LTBP-4 gene.
This mouse line contains the nuclear DNA of the C57BL/6N mouse, and mtDNAs both of C57BL/6N and a wild-derived house mouse.
McGarry and colleagues have reported that another transgenic mouse line contains two distinct, SST-positive cells that primarily occupy layers II and III [ 49].
Ms4Yah mice were obtained through in vivo chromosomal engineering using a mouse line containing loxP sites in a cis configuration and the Prmt2 and Cstb loci crossed with a general CRE deleter strain, Tg(CMVCRE) 1pcn.
We turned to commercially available transgenic mouse tools to determine if we could use a mouse line containing a GFAP promoter to drive expression in peripheral non-myelinating Schwann cells.
