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In this study, the ability of various cell types to activate P4, independent of the other virus host interactions, was examined in transgenic mouse lines bearing a β-galactosidase reporter sequence driven by the P4 promoter.
Two independent transgenic mouse lines bearing this fragment intact were generated and analyzed.
Three independent transgenic mouse lines bearing this construct were established (lines 10, 17, 22) with copy numbers of 3, 3, and 7, respectively.
TGFα-expressing transgenic (TG) mouse lines bearing human TGFα cDNA under the control of the mouse metallothionein gene I promoter were generated on a CD1 mouse background, and analyzed their ethanol injury-resistant phenotypes produced by TGFα.
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To evaluate the physiological function(s) of PDZ-RhoGEF, we generated a genetically modified mouse line bearing a conditionally targeted PDZ-RhoGEF allele, Arhgef11.
These studies were conducted in mouse embryonic fibroblast cell lines bearing Gq/11 and β-arrestin-1 and -2 gene deletions or disruptions and a mouse GnRH hypothalamic cell line expressing reduced levels of β-arrestin-1 and -2.
CEABAC transgenic mice (CEABAC2 and CEABAC10 lines, bearing 2 and 10 copies of the CEABAC transgene, respectively) were produced and maintained on the FVB strain background.
While one study observed an increase in TP53 expression in mouse Dkc1 mutant cells after etoposide exposure (Gu et al, 2008), another reported a decrease, both in mouse cells and human B lymphocyte lines bearing dyskerin mutations, due to an impairment in internal ribosome entry site (IRES -mediated TP53 translatIRES -mediatedTP53, 2010).
The MICER strategy was used to generate ES cell lines bearing segmental deletion or duplication of Abcg1-U2af1 on mouse chromosome 17 (30333543 to 31387432 bp), using ES cell line HM-1 as parental line [13], [15], [34], [35] (mES_14_Mono and mES_14_Tris, respectively).
Gene expression of MexTAg mesothelioma cell lines bearing a high or low number of copies of the TAg transgene were compared to wild type mouse mesotheliomas and normal mouse mesothelial cells using Affymetrix microarray.
Ten transgenic potato lines bearing patatin hpRNA were generated.
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