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A striking feature of this expansion in the mouse lineage, is that many of the RCL sequences are unique [ 29], novel sets of proteinases are being targeted.
However, 1,861 CNSs lost in the human lineage after the divergence from mouse is lower, and the 13,015 CNSs lost in the mouse lineage is higher than those lost in cow and dog lineages after their divergence.
Moreover, the outgroup for the analysis of the mouse lineage is very distant, whereas the outgroup for the analysis of the human lineage is much closer: mouse and human diverged between 85 and 95 Ma, whereas human and macaque diverged between 27 and 33 Ma Pouxx et al. 2006; Huchon et al. 2007).
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The HBV-Tg mouse lineage was initially produced on a BALB/c background.
In conclusion, the formation of the Pldi- Ak158810 loci, which became a pair of lncRNA genes in mouse lineage, was affected by multiple factors.
Furthermore, based on alignments of mouse-rat-human orthologous DNAs, the number of nucleotides that were ancestrally A or T before mouse-rat divergence (human and rat are both either A or T of the aligned site) and had a substitution event in the mouse lineage was calculated and defined as " Nsubstituted A/T" for each enhancer.
The extra keratin gene identified between K7 and K81 in the mouse lineage was already described by [ 16], but there is no other report for the new type II keratins identified in microbat, dog and horse genomes, neither for the extra mouse keratin located between K79 and K8.
We found that PDGs duplicated in the specific human and mouse lineages are significantly enriched at pericentromeric regions of human (P-value = 5.1×10−38, chi-squared test) and mouse (P-value = 4.4×10−5) chromosomes.
To compare our results with those of previous studies, correlation coefficients computed using CO in both human and mouse lineages are available in the supplementary material (Supplementary Material online).
The genetic predisposition for the development of eye autoimmunity, where only some mice lineages are susceptible to the induction of disease is quite clear in this model.
In the opposite case, the mouse lineage origin is the most parsimonious hypothesis.
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