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Thus, the Fgfr3-iCre-ERT2 mouse line is a useful tool for inducible gene inactivation in postnatal auditory supporting cells.
The defect in this mouse line is a deletion that includes exons 16 to 22 of Phex, although the exact extent of this X chromosome deletion remains unknown.
In summary, our FLPo deleter mouse line is valuable for gene manipulation and will facilitate the general process of generation of conditional knockout mice.
The R6/1 mouse line is one of the most widely employed models of Huntington Disease (HD), a complex syndrome characterized by motor and non-motor deficits.
Furthermore, dopaminergic neuronal loss is not observed in a second lower-expressing G2019S-LRRK2 line (line 1128) at a similar advanced age implying that neurodegeneration in the 340 mouse line is most likely due to higher transgene expression (Figure S4).
The LADY (also termed as LPB-Tag) transgenic mouse line is one of these mouse models.
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The R-Ras knockout mouse line was generated by Lexicon Genetics.
The GFP-D2 mouse line was established by crossing heterozygotes to derive a homozygote line.
Mouse embryos of the miR-132/212 knock out mouse line were generously provided by Prof. Arthur Simon, University of Dundee, UK.
A mouse line was produced in which cre was targeted to the Foxg1 (BF-1) locus, a gene expressed specifically in the telencephalon and discrete head structures.
This mouse line was designated as ΔCS.
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