Our results demonstrate that the DAT KD mouse line in the BPM is a consistent, reproducible model of mania-relevant behaviors.
To visualize the morphological subtypes of HS3ST-2/TrkC-expressing neurons, we generated a HS3ST-2-hPLAP knock-in mouse line, in which HS3ST-2-expressing neurons and their projections are labeled by human placental alkaline phosphatase (hPLAP).
To determine whether tissue-specific and inducible expression of the ANF gene can be segregated, we used a transgenic mouse line in which 500 base pairs of the human ANF promoter region directs atrial-specific expression of the simian virus 40 large tumor antigen (T antigen), with no detectable expression in the ventricles.
We next examined a BAT-gal transgenic mouse line in which β-galactosidase reporter is expressed under the control of β-catenin/Tcell factor responsive elements [25].
Despite the extensive use of the R6/1 mouse line in the last decade, its pre-motor phenotype has not been investigated in detail.
We employed the Cre recombinase/loxP system to create a mouse line in which PKA activity can be inhibited in any cell-type that expresses Cre recombinase.
Previously, we generated a conditional mouse line, in which the IFN-β coding sequence is replaced by the reporter luciferase upon cell specific Cre expression [30].
A knock-in mouse line in which the nicotinic acetylcholine receptor α4 subunit has been labeled with the YFP motif has been generated on a C57Bl/6 background and described previously [21].
Here, we report a mouse line in which an Epstein-Barr virus Latent Membrane Protein 1 (LMP1) transgene insertion has created a 7.2-kb chromosomal deletion, which abolished RASSF9 gene expression.
To characterize Runx1 expression in the developing brainstem, we used a previously described Runx1lacZ/+ knock-in mouse line in which the expression of ß-galactosidase (ß-gal) faithfully replicates Runx1 transcript and protein expression [13] [16].
First, we labeled a subpopulation of cortical neurons mainly fast-spiking interneurons by using adeno-associated virus (AAV) to deliver ChR2 in a transgenic mouse line in which the expression of Cre recombinase was driven by the parvalbumin promoter.
