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Studies on the R6/1 model so far have employed mice of either sex, and sex differences in the severity of HD-like symptoms in this mouse line have not been systematically investigated.
Problems with the osterix-cre mouse line have been described.
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The COET transgenic mouse line has been described previously [23].
The OPN KO mouse line has been backcrossed into the C57Bl/6J background >10 generations.
Generation of the 5 kb rat Gata4 promoter 1a-GFP transgenic mouse line has been described previously [29].
Cre expression in this mouse line has previously been demonstrated to be specific for vascular and visceral SMCs [28].
Cell death in the hippocampus from single systemic injections of KA in this mouse line has been previously described [2].
A Plxdc1 knockout mouse line has also been analysed and showed no obvious phenotype in the central nervous system (data not shown).
In addition, the same floxed Atrx mouse line has been used by us and others to successfully conduct loss of function studies in other organs, such as the brain [7], [8] or eye [9].
This mouse line has been shown to be bona fide in vivo indicators of Wnt/β-catenin signaling, allowing visualization of the general status of Wnt activation in cells in a given tissue.
This mouse line has been described elsewhere [ 20].
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CEO of Professional Science Editing for Scientists @ prosciediting.com