Out of 21 independent Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) transgenic mice, one mouse line exhibited intriguing phenotypes showing growth retardation, alopecia and short lifespan in homozygotes (−/−; Figure 1A C), and signs of haploinsufficiency for heterozygotes for the alopecia (Figure 1A).
These results show that the gene trap mouse line exhibits the early embryonic defects in growth and loss of viability previously described (Mu et al., 2010).
Unexpectedly, a C57BL/6-Tg (ITF-TMEM207) mouse line exhibited a high incidence of spontaneous intradermal tumors with histopathological features that resembled those of various human cutaneous adnexal tumors.
Based on these histological features, we conclude that the C57BL/6-Tg (ITF-TMEM207) mouse line exhibited a high incidence of cutaneous adnexal tumors, which sometimes exhibit the malignant invasive phenotype.
Both viral-mediated infection of GABAergic neurons in the SNr and the Thy1-ChR2 transgenic mouse line exhibited cell-type specific expression of ChR2 in GABAergic neurons of the SN, but not in dopamine neurons.
The Lean mouse line exhibits characteristics that uncover some of the factors involved in genetic predisposition for obesity-resistance that may also be relevant for obesity and metabolic syndrome basic and applied research in humans.
LmnaE82K transgenic mouse lines exhibited thin-walled, dilated left and right ventricles, a progressive decrease of contractile function assessed by echocardiography.
At the same time, all four cerebellar mutant mouse lines exhibited poor interlimb coordination.
Bmp4 and Bmp7 loss-of-function mouse lines exhibit pre-axial polydactyly (Dudley et al., 1995; Luo et al., 1995; Dunn et al., 1997; Selever et al., 2004).
Only in the α6-Cacna1a mice we observed a gradual increase in the occurrence of large steps (for p values, see Table 1).> -wrap-foot> Withethexceptionof of Pcd mice, all the cerebellar mutant mouse lines exhibited changes in their locomotion parameters over the course of the sessions.
