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To examine the importance of sFasL in ocular homeostasis and RGC degeneration, we constructed a FasL-deficient mouse line (designated as FasL KO) and a membrane-only FasL gene-targeted mouse line (this cleavage site deleted-mouse line was designated as ΔCS).
Recently, a transgenic mouse line, designated as TgTSPY9 harboring the human TSPY gene on the mouse Y-chromosome, has been established [ 43].
Ma et al generated a mouse line designated as X94, whereby GFP expression (encoded for by random insertion of the GFP gene) was controlled by the GAD67 promoter; cells from this line express SST but differ from Martinotti cells in many aspects [ 48].
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In order to unravel the pathological properties of TMEM207, we generated several transgenic mouse lines, designated C57BL/6-Tg (ITF-TMEM207), in which murine TMEM207 was ectopically expressed under a truncated (by ~200 bp) proximal promoter of the murine intestinal trefoil factor (ITF) gene (also known as Tff3).
To explore the pathological properties of TMEM207 in gastrointestinal tumors, we originally generated several C57BL/6-Tg (ITF-TMEM207) mouse lines, designated C57BL/6-Tg (ITF-TMEM207), in which murine TMEM207 is ectopically expressed under the proximal promoter (truncated by ~200 bp) of the murine intestinal trefoil factor (ITF) gene (also known as Tff3).
As mature podocytes lose proliferative capacity, a conditionally SV40 mutant tsA58-immortalized mouse podocyte line (designated as tsPC) was established from the Immortomouse over 20 years ago.
In this study, we establish a user-friendly and reversibly-immortalized mouse podocyte line (designated as imPOD), on the basis of the tsPC cells by stably expressing the wildtype SV40 T-antigen, which is flanked with FRT sites.
Of the three breeding lines of HD118-eGFP mice, the line designated S22 expressed the highest level of htt; however, the level was ∼50% lower than that of HD-N171-82Q line 81 mice (Fig. 2A).
In this study, Cameron Johnstone, Yvonne Smith and colleagues used a mouse breast cancer line, designated EO771, derived from a spontaneous mammary tumour of a C57BL/6 mouse.
The tamoxifen-inducible, knock-in mouse line Shhtm2 (cre/ERT2)Cjt (designated as ShhCreERT2) (37) was used to induce the conditional mutation of Bmpr1atm2.1Bhr (designated as Bmpr1a-flox) (38).
This mouse line was designated as ΔCS.
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