Sentence examples for mouse line combined from inspiring English sources

We developed a novel gene replacement approach for the calyx of Held synapse, which makes use of a floxed mouse line, combined with virus-mediated expression of three proteins: (i) Cre-recombinase; (ii) the protein of interest in mutated, or wild-type form, and (iii) the reporter gene GFP.

Indeed, in the present study we have combined our new mouse line with a nestin rtTA line to investigate the involvement of neural progenitor subtypes in the establishment of brain size and morphology during embryonic development.

The ALL-16 xenograft line was established from a patient T-ALL diagnosis sample in the Non-Obese Diabetic/Severe Combined Immunodeficient (NOD/SCID) mouse line as previously reported [ 2].

By combining a Tbx4-rtTA driven Tet-On inducible Cre expression mouse line with a Cre reporter mouse line, the spatial-temporal patterns of Tbx4 lung enhancer targeted lung mesenchymal cells were defined.

We further combine αMHC-H2B-mCh mice with the CAG-eGFP-anillin mouse line for unambiguous visualization of cell cycle progression and division of postnatal CMs and for establishing a screening assay for cell cycle-modifying substances.

These and other questions can be addressed through further experiments making use of the existing KO mouse lines and novel transgenic models, combined with state-of-the-art cell biological, developmental, signaling, and molecular imaging techniques.

By combining a TCRβ transgene with a TCRα minilocus comprised of a single V and two J gene segments, we engineered a mouse line exhibiting ample but focused TCR diversity, restricted to CDR3α.

Here, we have combined genome-wide ChIP followed by massively parallel DNA sequencing (ChIP-seq) and whole-transcriptome RNA sequencing (RNA-seq) using embryonic hearts from a mouse line that shows hypomorphic expression of NKX2-5 and models human cardiomyopathy.

The R-Ras knockout mouse line was generated by Lexicon Genetics.

This mouse line was designated as ΔCS.

In the future, the pneumonectomy mouse model combined with genetically modified mouse lines, lineage tracing approaches, and single-cell transcriptomic analyses will be powerful tools to shed new lights on the regenerative aspects associated with de novo alveologenesis.