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Using classical Pavlovian fear-conditioning paradigms, we have demonstrated that a mouse line characterized by extremely high innate anxiety-related behaviour (HAB) expressed more contextual- and cue-dependent fear relative to NAB controls.
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Each mouse line is further characterized with gene expression data and phenotypes.
Five TRE-claudin-1 responder mice lines were characterized for expression of claudin-1 and GFP (11 mice for line 23949, 12 mice for line 23954, 10 mice for line 23970, 19 mice for line 23971 and 8 mice for line 23974).
Although constructing gene-targeted mouse lines is more labor intensive than constructing BAC transgenic mice, it has the virtue that only one knock-in mouse line needs to be characterized for each construct.
A 'floxed CNTFRα' mouse line was generated and characterized.
The PoPrP-Tg001 mouse line was generated and characterized as previously described (8 ).
The mouse lines established and characterized in this study offer new models to study ER-related myodegenerative process that occur in myopathies such as sporadic or hereditary IBM.
Interestingly, the two different PSA-deficient mouse lines are both characterized by abnormal motor behaviour (17, 21), which might also be a consequence of reduced autophagy, since the blockage of this process in Atg7-deficient mice leads to major behavioural deficits and widespread inclusion bodies (32).
injection in nude-SCID mice of EBV− Burkitt-type BJAB and EBV+ B lymphoblastoid SKW6.4 cell lines, characterized by an indolent (BJAB) and an aggressive (SKW6.4) behavior.
We present a new double reporter mouse line that helped to characterize the activity pattern of miR-9 in different cell types in the brain.
† Indicates lines characterized in greater detail.
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