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Two recent publications have reported that gramisterol isolated from the rice bran extract displayed not only anti-cancerous activity against the mouse leukemia cell line, but also anti-tumor and immune enhancing activities against acute myelogenous leukemia (Suttiarporn et al. 2015; Somintara et al. 2016).
A previous study in a mouse leukemia cell line demonstrated that AZA incorporated into RNA and DNA at a ratio of approximately 85∶15, respectively [4].
Here we use epigenomic tools to simultaneously interrogate chromatin modifications and DNA methylation in a mouse leukemia cell line, L1210.
We first performed chromatin ChIP-chip on the mouse leukemia cell line, L1210, with antibodies detecting either acetyl-H3K9 or dimethyl-H3K9.
Similar results were observed in the WEHI-3B mouse leukemia cell line and to a lesser degree in mouse embryonic fibroblasts (MEFs).
We selected a single mouse leukemia cell line, L1210, in this study and conclusions drawn in this system will need to be validated in other mammalian cells.
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Dansylated polytheonamide mimic (2) is an ion channel peptide which displays potent cytotoxicity against P388 mouse leukemia cells (IC50 = 12 nM).
These secosteroids inhibited proliferation and induced erythroid differentiation of K562 human chronic myeloid and MEL mouse leukemia cells with 20(OH)D3 and 20,23 OH 2D3 being either equipotent or slightly less potent than 1,25(OH)2D3, while 1,20(OH)2D3, pD and pL compounds were slightly or moderately less potent.
A previous report showed that TFP enhanced G2-M arrest in mouse leukemia cells exposed to bleomycin.
Mouse leukemia cells were isolated from markedly enlarged spleens of CD22ΔE12-Tg CD22ΔE12-Tg or Eμ-MYC Tg mice, splenocytes from wildtype healthy C57BL/6 mice served as controls.
Authors transplanted Sin1+/+ or Sin1−/− p210 BCR-Abl transformed mouse leukemia cells into wild type mice and treated the recipients with 17-AAG or vehicle for five days.
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mouse leukemia cells
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