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In the mouse, lack of p53 leads to impaired cardiorespiratory fitness and loss of aerobic competence.
In mouse, lack of Rab-GDI perturbed the functionality of different SV pools at the presynaptic site.
Even for a genome for which alternative splicing has been extensively studied, such as human or mouse, lack of a de novo event finding tool limits the power of studying events that are not previously documented.
Staining of these tissues confirmed that the gastrodermal epithelial and hair matrix cells in rat, similarly to mouse, lack MECP2, whereas the nuclei of muscle cells (smooth, skeletal, and heart muscles) had a strong punctate MECP2 signal in the nucleoplasm.
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After a knock-out mouse lacking the gene known as Msx1 was generated, a human family was found who lacked one of their two copies of the gene.
The CaSR−/− mutant mouse lacks CaSR exon 5 which results in a reduced affinity for Ca2+ [29].
Long-lived Ames dwarf mice lack growth hormone, prolactin, and thyroid stimulating hormone.
mdr1a-deficient mice lack P-glycoprotein and spontaneously develop colitis with age.
N. brasiliensis-infected Il17rb −/− mice lack iILC2 cells and, interestingly, nILC2 cell numbers are significantly decreased in these mouse models.
These mice lack commissural fibers [1].
Rag−/− mice lack T cells and therefore lack ICOS+ cells.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com