Sentence examples for mouse knowledge assembly from inspiring English sources
Each such causal assertion has a specific scientific citation, and the assembled collection of these causal assertions is referred to as the mouse knowledge assembly model in this paper.
The substrate for analysis of RNA state changes observed in the SRT501 dataset comparison is the mouse knowledge assembly model, which is derived from a global Genstruct knowledgebase.
Hypothesis generation is performed automatically by a computer program that utilizes the mouse knowledge assembly model to identify hypotheses that explain the input RNA state changes, prioritized by multiple statistical criteria.
The mouse knowledge assembly model is the set of mouse-specific causal assertions that has been augmented with orthologous causal assertions derived from either rat or human sources and is competent for reverse causal analysis.
In the case of RNA expression data, Causal Network Modeling employs an automated reverse causal analysis approach which interrogates the mouse knowledge assembly model to identify upstream controllers for the RNA state changes observed in the experiment.
Using both the information stored in the mouse knowledge assembly model and from literature investigation, causal links between selected hypotheses were identified enabling incorporation into an overall biological network capable of explaining the effects of SRT501 treatment, called the Causal Network Model (CNM).
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To utilize the SD pair data from the mm8 mouse genome assembly, we translated the coordinates of the miRNA genes from the mm9 mouse assembly to the mm8 assembly using the liftOver utility [42] provided by UCSC Genome Browser [41].
All reads were realigned to the NCBI m37 version of the mouse genome assembly using the Bowtie [26] short read alignment program considering the 22 chromosome assemblies.
Scores are available for the mouse mm8 assembly.
For annotation, matched human and mouse tags were mapped to human (Mar. 2006 assembly, hg18) and mouse (Aug. 2005 assembly, mm7) genomic sequences, respectively, using BLAT [ 20].
