Sentence examples for mouse knockout of from inspiring English sources

It has been shown that mouse knockout of the LH receptor leads to an arrest of Leydig cell differentiation at progenitor Leydig cell stage [3], [4].

In this study, we used a Tek-driven conditional mouse knockout of Ate1 to show that Ate1-mediated protein arginylation plays a previously unknown role in germ cell development.

In mouse, knockout of either isoform is lethal, further emphasizing the functional importance of the protein (Ranade et al., 2014a).

Furthermore, we use a mouse knockout of Lrpprc and show that loss of complex IV compromises respirasome formation.

The mouse knockout of Esco2 is eight-cell-stage lethal, which unfortunately limits in vivo multicellular analysis (Whelan et al., 2012).

In mouse, knockout of the PI3K domain of Pdgfra leads to craniofacial defects, which mimic the full knockout phenotype (Klinghoffer et al., 2002).

Although htt ko mice were embryonic lethal [17], mouse knockouts of SCA genes survived normally into adulthood.

Likewise failure to repair the DNA breaks is also deleterious as demonstrated by examination of mouse knockouts of genes involved in recombination repair pathways shown to result in male infertility [12], [13].

Mouse knockouts of several transcription factors such as MafB, Phox2a, Phox2b, Rnx, and Mash-1, have been shown to affect different groups of respiratory neurons in the brainstem resulting in respiratory phenotypes and death at or shortly after birth [30].

As would be expected for a potent gene regulator, mouse knockouts of miR-155 [43], [43] and miR-1-2 [44] demonsthate that thesethese microRNAs are essential for normal immune function and cardiac development, respectively.

Interestingly, fruit fly and mouse knockouts of the clock gene period display diel clock gene expression under natural light cycles and arrhythmic clock gene expression under constant dark conditions [33], [34], [35].