Sentence examples for mouse knockout is from inspiring English sources

P130Cas is ubiquitously expressed [10], and the mouse knockout is embryonic lethal with Cas −/− mouse embryonic fibroblasts (MEFs) having disorganized actin stress fibers and defects in cell migration [11].

In this case, a mouse knockout is already available for the researcher.

> Query 2 identifies genes expressed in the heart or sub-structures and which IKMC project is producing knockouts of these genes, the status of this pipeline and whether vector, ES cells or a full mouse knockout is available to order.

Query 1 identifies genes encoding transcription factors in this region and the IKMC project that is producing knockouts of these genes, the status of this pipeline and whether vector, ES cells or a full mouse knockout is available to order.

A similar situation exists in mice where a Dcps mouse knockout is reported to be embryonic lethal (20) while a mutant Dcps mouse line, referenced at the Mouse Genome Informatics (MGI:1916555) is viable but phenotypic information is unavailable.

An impressive array of auditory and vestibular mouse knockouts is already available as a valuable resource for studying the ontogenesis, morphogenesis and function of the mammalian inner ear.

Importantly, a TRPML1 agonist, whose specificity was confirmed with mouse knockouts, was shown to be cell permeable with reversible effects (Shen et al., 2012; Garrity et al., 2016).

The importance of this PTM to cellular growth is probably best exemplified by the fact that both PRMT1 and CARM1 mouse knockouts are embryonically lethal.

Atf2Δepiblast mice knockouts were produced by crossing Atf2f/+ meox2-Cre mice with Atf2f/f mice.

Effects of genetic background on the phenotype of targeted mutations in mice (knockouts) are widely appreciated, and most are backcrossed into C57BL/6 or another suitable strain.

In mice, Wls knockout is embryonic lethal similar to the Porcn knockout with failure of mesoderm induction and gastrulation [ 95].