Sentence examples for mouse knockout approach from inspiring English sources

Using a conventional mouse knockout approach Aqeilan et al. [20] reported development of osteosarcomas in some Wwox−/− mice by the age of 2.5 weeks and as early as postnatal day 3.

Moreover mouse knockout approaches to prove their role in fertilization has been found tedious since the absence of one component during spermatogenesis or sperm epididymal maturation may result in improper formation of specialized sperm membrane surface domains [ 9, 12, 13].

The physiological function of a given molecule or its significance in development in vivo can be studied by taking a knockout approach in mouse.

By using an inducible conditional knockout approach in adult mice, we demonstrate that Cited2 deletion results in an acute loss of HSCs, at least in part via apoptosis, subsequently causing multilineage BM failure.

Here we investigated functions of c-Myc during mouse mammary gland development using a conditional knockout approach.

Here, we extended this gene knockout approach to Ehd3; however, Ehd3 /– mice showed no discernable pathology.

This approach revealed that 7 lincRNAs from our mouse knockout strains have human orthologs that are dynamically induced during in vitro human neuronal differentiation.

Mouse knockout studies support this role.

These conditional knockout mice represent an alternative approach to overcome the lethality of gene deletion that can be encountered in a traditional global knockout approach.

This is compatible with mouse knockout studies.

The generation of mouse knockouts has been a commonly used approach to study gene disruption in the context of a whole organism.