Exact(2)
We also examined the effect of Ex-4 and GLP-1 on oxygen consumption at different glucose concentrations in rat and mouse islets since this parameter reflects overall fuel utilization and metabolic activation of a given tissue.
In the case of the HNF1B gene, the conditional deletion was been carried out in adult (or at least partly differentiated) mouse islets, since the insulin gene was used to target the beta cells for gene knockout [8].
Similar(58)
Since the interior of mouse islets consists almost entirely of β cells (other cell types being concentrated on the outside) this technique ensured the pH measurements being performed in β cells.
86 In addition, fatty acids can have a toxic effect on β-cells, since treatment of human or mouse islets with palmitate induces apoptosis.
In summary, human and mouse islets share common architectural features as endocrine micro-organs.
The Purdue and IU team removed the need for transplanting in the liver by mixing mouse islets with the collagen solution.
PSN632408 and an endogenous ligand of GPR119, oleoylethanolamide (OEA), can stimulate β-cell replication in mouse islets in vitro.
Mouse islets were isolated by collagenase digestion of the pancreas according to previously described procedures (Martinez et al. 2006).
Mouse islets were isolated as described previously [36].
At least five islets were chosen randomly from control or βIRKO mouse islets and ∼4 randomly selected β-cells from each islet were photographed.
Isolated mouse islets.
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