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Since microvilli serve to augment the absorptive surface of the intestine, their reduction in Eps8KO mice is compatible with the absorption defect and with the calorie restriction phenotype that we observed in these animals.
The differential gene expression profile observed in the striatum of Pink1-deficient mice is compatible with neuroprotective adaptations to increased MAP kinase signaling and inflammation in the Pink1−/− brain.
The lack of a phenotype despite the reduced numbers of T cells in the periphery of DG/Lck-cre mice is compatible with earlier studies that documented clearance of LCMV infection requires ∼350,000 virus specific CD8+ and 7,000 CD4+ T cells [30] and that diminished thymic input of T cells has a minimal impact on the control of LCMV infection [31].
The authors showed that simultaneous deficiency of three methyl-CpG binding proteins MECP2, MBD2, and KAISO in mice is compatible with normal embryogenesis and provided evidence for redundancy of function between these proteins in postnatal mice.
Although complete deficiency for SEC24B or SEC24A in mice is compatible with embryonic development or survival to adulthood, respectively, no human patients have yet been identified with genetic deficiencies in any of the four SEC24 paralogous genes.
Our imaging data in mice are compatible with this explanation as bioluminescent bacteria were clearly located in the skull and bacteria were detected in CSF.
Both the age-dependent deficits in spatial reference memory and the severe hippocampal neuron loss in homozygous Tg4-42 mice are compatible with AD-typical changes.
Hence, the strong phenotype that we observed in our transgenic mice was compatible with Snail1 inducing a defect in bone formation, and on the other hand, it is very reminiscent of osteomalacia or defective bone mineralisation (Karsenty and Wagner, 2002).
Moreover, it remains to be determined whether the most striking variation of the H-Y-E motif – to Q-Y-T in human and mouse pART9 is compatible with enzyme activity.
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