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Camargo and colleagues described a growth suppressive function of YAP in the mouse intestine and a silencing of YAP in a subset of human colorectal carcinomas[31, 32].
Indeed, YAP targets Epiregulin and CTGF have been shown to promote tissue repair in the mouse intestine and zebrafish spinal cord, respectively (Gregorieff et al., 2015; MH et al., 2016).
In this review, we summarize methodology for the isolation and phenotypic characterization of macrophages and DCs from the mouse intestine and discuss how this may be useful for gaining insight into the mechanisms by which mucosal immune tolerance is maintained.
We engineered the enteric bacterium, Escherichia coli, to manipulate the levels of the interspecies quorum sensing signal, autoinducer-2 (AI-2), in the mouse intestine and investigated the effect upon antibiotic-induced gut microbiota dysbiosis.
PCR of AvrA further confirmed that AvrA was expressed in the mouse intestine and feces (data not shown).
Similar observations have also been observed in vivo in mouse intestine and spleen [4] where damped p53 pulses with periods of 4.5 to 6 hrs are reported.
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To study a direct effect of gluten on NKG2D ligand expression, we performed qPCR analyses of a number of known NKG2D ligands in mouse intestines and isolated islets.
Collectively, the above results from mouse intestines and Drosophila midgut strongly suggested that Rab11-deficient enterocytes triggered cell-autonomous cytokine productions that indirectly impacted IESC proliferation.
As shown in Supplementary information, Figure S4, an ∼10-fold increase in MIR2911 level was also detected in the liver, while the levels of MIR2911 in the mouse intestines and kidneys remained unchanged.
These lysozyme-positive cells in the colon could be the 'intermediate cells' in transition between Paneth cells and goblet cells, described previously in the mouse intestine (Troughton and Trier, 1969).
A similar process has been shown to occur in the mouse intestine, oesophagus and other tissues (Clayton et al., 2007; Snippert et al., 2010; Doupe et al., 2012).
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