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Mortality occurred in nearly all inoculated mice; one mouse inoculated with 104 CFU survived beyond the study window of 216 hours after inoculation and was sacrificed.
DNA was also detected in the subcutaneous mass and lymph node of another mouse inoculated with Th339, 5 weeks post-inoculation.
B. tamiae DNA was detected 3 weeks post-inoculation in a subcutaneous mass and the liver of a mouse inoculated with Th339.
After second passage, PrPres was detected in a single mouse inoculated with one of the three H-BSE isolates.
In three repeated sPMCA experiments, a subclinical prion infection was confirmed in the remaining mouse inoculated with tissue from deer #134 (mouse #Tg 2-B).
Data showing that a clusterin knockout mouse inoculated with BSE prions has a significantly increased incubation time suggested that Clu was a particularly good candidate quantitative trait gene for prion disease incubation time [25].
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Age-matched non-inoculated or mice inoculated with normal brain comprised negative controls.
Ten days after inoculation, xenograft tumors formed in mice inoculated with parent HEK293 or hBD-3 overexpressing cells.
Nude mice inoculated with both MLK3 mutants developed subcutaneous tumours within 5 weeks after inoculation.
Griffith found that mice inoculated with either the heat-killed virulent bacteria or the living avirulent bacteria remained free of infection, but mice inoculated with a mixture of both became infected and died.
It prolonged the life span of mice inoculated with Ehrlich carcinoma or L1210 [25].
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