In mice infused with P301SBE, the infused hippocampus had significantly more inclusions than the contralateral hippocampus, whereas no such differences were detected in the WTBE or PBS groups.
Similarly to what happened in sham-operated mice, in ischemic mice infused with NC 7 d) the infused cells did not persist in the brain tissue, but they were instead rapidly eliminated, indicating that at this time point the ischemic environment has lost its ability to promote NC survival.
Plasma GIP concentrations were sevenfold higher in Apoe−/− mice infused with GIP vs vehicle-infused controls, whereas GLP-1 concentrations were only fourfold higher than the control level in Apoe−/− mice infused with GLP-1.
By immunoblot analysis, compared to tg mice infused with vehicle alone, α-syn tg mice that received intra-cerebral infusions with rapamycin displayed reduced levels of α-syn in the membrane fraction with a concomitant increase in the lysosomal fraction (Figure 8O, P).
Similarly to what observed in sham-operated mice, in ischemic mice infused with NC 7 d) only few cells could be observed 1 day after infusion (day 8 from ischemia) and no cells could be found at day 14 (n = 6).
In each case, the biochemically "hungry" mice — mice infused with ghrelin — performed notably better than those with normal levels of the hormone.
In uncultured mouse adipose-derived cells (ADCs), the TF-triggered procoagulant activity was not observed and all mice infused with these uncultured ADCs survived after 24 h.
Naive and preimmunized mice infused with hFVIII expressing tDCs showed suppression of the T cell and inhibitor responses to recombinant hFVIII (rhFVIII).
Consistent with findings in the rat undercut cortex, the percentage of PV/WFA interneurons in the mouse hippocampus was significantly decreased following 7 days of albumin exposure, compared to control mice infused with aCSF (Fig. 5b and Supplementary Fig. S5).
Treatment of hypertensive mice with mCP1 and mCP2 (1.4 mg/kg/day) after onset of angiotensin II-induced hypertension significantly reduced blood pressure to 133±5 mmHg and 129±6 mmHg compared to 163±5 mmHg in mice infused with angiotensin II alone.
Unexpectedly, pronounced abdominal aortic aneurysms were present in apoE mice infused with Ang II.
