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We recently described the kinetics of parasite-specific cytotoxic CD8+ T cell responses following mouse infection with the human protozoan parasite Trypanosoma cruzi [13].

In initial experiments using higher doses of bacteria, ranging from 4.5×106 to 8×106 bacteria per mouse, infection with the sigS mutant gave rise to significantly less mortality when compared to animals infected with SH1000 (Fig. 6A).

During mouse infection with HSV-1 mutants possessing HSV-2 LAT regions (and vice versa), these preferential sites swapped between viruses, defining the LAT as the viral determinant of this specificity (Margolis et al., 2007; Imai et al., 2009).

In spite of an initial increase in bacterial burden typical for mouse infection with virulent R. equi, bacterial counts were 40 60% lower for 103+/ kasA than for 103+ bacteria at 2 days, 4 days and 8 days (Fig. 6E).

We report that mouse infection with N. aromaticivorans induced antimitochondrial IgG antibodies and the development of chronic bile duct lesions and lymphoepithelioid granulomas similar to PBC, in a CD1d-dependent manner.

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Because mouse infections with attenuated subsp. novicida strains provide little to no protection against subsequent subsp. tularensis challenge, this subspecies has been ignored largely as a potential tularemia vaccine platform.

Using PAD1 as a marker, MacGregor et al. [ 8] showed that in chronic mouse infections with pleomorphic trypanosomes, stumpy forms initially appear in the blood when parasitaemias exceed 10/ml.

The researchers found that in mice, infection with a particular virus triggers a surge in interleukin-33 (IL-33).

As a matter of fact, mice infection with specific pathogen and/or opportunistic agents could lead to chronic inflammation that is known to modify prion infection [16].

In immuno-competent mice, infection with 105 to 106 virulent B. pertussis results in a typical increase of the bacterial burden by a factor of 10 during the first 7 days, followed by a general decline with a total clearance of the bacteria at day 30 after infection [21], [23].

BRSN and AMB made BALB/c mice infection with Paracoccidioides Pb18.

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