In an oral mouse infection model, the vaccine strain Z234-pMS101 efficiently colonized the host gut.
Informative vaccine research has been conducted in the mouse infection model of a closely related rodent virus, murine gammaherpesvirus-68 (MHV-68 or γHV-68).
The expressed rOmpF protein induced an effective immune response, but only provide a weak protection against pathogenic E. coli CVCC 1515 and a small reduction in E. coli CICC 21530 (O157 H7) excretion in a mouse infection model.
More importantly, due to their intrinsic absorption of NIR light, glutaraldehyde-modified PEG-W18O49 are successfully applied as fault-free targeted photothermal agents for imaging-guided killing of bacteria on a mouse infection model.
The syntheses of eight of the most potent in vitro compounds were scaled up and the compounds were tested in an in vivo mouse infection model to evaluate their efficacy before engaging upon more elaborate compound design and optimization.
In a mouse infection model of Listeria monocytogenes, the SCT DNA vaccine encoding H-2Kd and the immunodominant peptide LLO 91 99 generated functional primary and memory peptide-specific CD8+ T cells that confer partial protection against L. monocytogenes infection.
This included four times larger amount of released silver ions, two times larger zone of inhibition, and one additional order of magnitude of reduction in numbers of CFU in an ex vivo mouse infection model.
In the mouse infection model, this virus induces acute encephalitis similar to that in piglets [4].
Consequently, we tested a commercially available nasal spray containing iota-carrageenan in an influenza A mouse infection model.
To validate this hypothesis, we investigated the biological impact of NO-np on MRSA using a mouse infection model.
This factor has been found to be involved in S. typhimurium virulence in a mouse infection model [28].
