The comparison revealed a significant reduction in the number of bifurcations and branches, and of the total microglial process length, in adult APPSw,Ind Tg mice compared with age-matched WT and young APPSw,Ind Tg mice, resulting in values similar to those observed in old WT mice (Fig. 3B D).
Mice injected with AAV9-gfaABC1D GFP miR AAV9-gfaABC1D GFP miRcant decreashowed< 0.001 compared to PBsignificantWT mice) in CMAP values between decreaseand 60.
The heterogeneity in myofibre CSA observed in SD-treated mdx mice, in which values ranged between 250 and 3000 μm, with the largest diameters being a sign of degeneration (pathological hypertrophy), was normalised in LPD-treated animals, with significantly more homogeneous frequency histograms and CSA values not significantly different from those observed in WT animals.
Comparison of data sets from acutely exposed mouse and zebrafish revealed two molecular responses in common, i.e. the altered activity of steroid hormones synthesis/signalling biofunctions, and the prediction of aromatase (Cyp19A) as upstream regulator (p-value = 4,95E-05 in mouse, p-value = 4,68E-05 in zebrafish), in agreement with the detection of trace chemicals affecting fertility [ 40].
While there are great efforts to test drugs in vivo in mice, the value of veterinary tumors as a comparative in vivo test is frequently underestimated.
In addition, although PSCR was apparent (p-value < 10−7), a significant overall post-meiotic upregulation of X-linked gene expression was observed in mouse (p-value < 10−15), but not in dog spermatids.
Values of vehicle-treated (control) mice are displayed in black (triangles), values of GM6001-treated mine in grey (circles); values of animals with monocular deprivation (+MD) are marked by displaying the right half of the symbol in black.
Although there are no data on fetal aortic blood pressure in mice, this value is similar to that seen in human fetuses at a similar state of embryonic development; fetal aortic blood pressure was estimated to be 28 mmHg at 20 wk rising to 45 mmHg at 40 wk of gestation (41).
We find heart rate variability to be lower in neonates than in adult mice, with values in young neonates (PND2-4) particulowlowlow.
Blood oxygenation levels of ~50% were found in the anaesthetized mouse; this value dropped to 0% immediately (< 1 min) after administration of the euthanasia solution.
