Sentence examples for mouse heart proteome from inspiring English sources

Comparison with a mouse heart proteome revealed conservation at the level of molecular function, biological processes and cellular components.

The comprehensive mouse heart proteome does include proteins under-represented in our dataset, however, notably kinases, certain ion channels and transmembrane receptors.

But more importantly, the classes of proteins identified and enriched in our dataset mirror those found in a recently published comprehensive mouse heart proteome [33], which we used as a benchmark.

The conservation between the Drosophila and mouse heart proteomes also bodes well for the implementation of systems biology approaches that include, among other techniques, computational modeling and proteomic network perturbation, to assess mechanistic commonalities between these model organisms.

A recent analysis of the mouse heart ubiquitinated proteome shows that proteins localized in mitochondria represent a major fraction (38%%) and expands the list of the ubiquitin conjugated mitochondrial proteins [33].

Though the extent of proteome coverage lags that of the well-studied mouse heart (4906 proteins) [33], through a combination of extensive dissection (100 Drosophila hearts can be harvested in a day) and careful data validation, we have compiled 1228 protein clusters from an organ whose mass is about 1/106 that of mouse heart.

The observation that the basal levels of HS-related proteins were reduced in the hearts of old mice was an interesting new finding as it does not seem to be a general property of the heart proteome (39).

Transgenic expression of DN-Lats2 was used to inhibit endogenous Lats2 in the mouse heart.

Figure 1 Mouse heart MR (left) and fused with 18F-FDG static PET (right).

To compare the mouse oocyte proteome with other mouse tissue proteomes, we generated a combined database for the mouse based on the following mouse tissues and cell cultures characterized by LC-MS/MS: mouse heart [ 51], liver [ 51- 53], brain [ 51, 54], lung [ 51, 55], kidney [ 51], spleen [ 56], placenta[ 51], cortical neurons cell culture[ 57], sperm [ 58], islet alpha-cell culture [ 59].

Differences in the cardiac 2-DE proteome pattern between nonhypertensive (Wistar-Kyoto rats) and spontaneously hypertensive rats (SHR) [ 39] support this, while several other studies show modulations in the heart proteome followed by pressure overload hypertrophy [ 40].