Sentence examples for mouse heart development from inspiring English sources
These results demonstrate that not only RCAN1.4 is expressed in hearts, but also its expression is differentially regulated, at least during mouse heart development, suggesting that the expression level of RCAN1.4 might contribute to human CHD.
These results suggest that Tbx3 is an important regulator of the rate of proliferation in the AVC and reveal that the role of Tbx3 is conserved in zebrafish and mouse heart development.
Surprisingly, this mouse Nkx2.5-knockout embryo does not exhibit the same defective phenotype of tinman null embryos, indicating that there are other Nkx2.5 homologs to compensate for Nkx2.5 loss of function in mouse heart development.
Unlike SMYD1, cardiac-specific knockout of Smyd2 has no phenotype during mouse heart development [ 114].
Indeed, the past decade has witnessed a dramatic increase in our understanding of mouse heart development, driven primarily by the use of genetic manipulation.
Based on studies of human and mouse heart development and mESCs, efforts were undertaken to derive cardiac progenitor cells from hESCs.
We determined the spatial expression of selected candidates by in situ hybridization at mouse E7.5, E8.5, and E9.5, critical time points for mouse embryonic heart development.
One possible underlying cause for a more relaxed purifying selection on heart enhancer is that during mouse embryogenesis, heart development begins and finishes earlier than brain and limb developments.
Here, we show evidence, for the first time, that pericytes differentiate into smooth muscle cells during coronary artery development in the mouse heart and developing kidney.
Inactivation of the Hippo pathway, which restrains cell proliferation and thus controls organ size in Drosophila, in the embryonic mouse heart results in development of enlarged hearts which display increased numbers of CMs and increased CM proliferation [ 75].
Grem1-null mice show intact heart development, despite impairment of lung and kidney [31], and therefore Grem1 is considered not to be involved in cardiogenesis, or supplementary factors such as Noggin [32], with a similar function, may compensate Grem1 during development.
