Sentence examples for mouse has proven from inspiring English sources
In conclusion, the C/EBPβ knockout mouse has proven a useful model in determining that C/EBPβ is critical for mammary gland development.
The SOD1 G93A transgenic mouse has proven to be an invaluable tool for studies of SOD1 ALS and the toxic gain of function acquired by the mutant protein.
Conditional mutagenesis in the mouse has proven to be remarkably powerful since its first application [ 46] and the addition of ligand regulation [ 15- 17, 47- 49] has further increased its precision.
The mouse has proven to be the most informative system demonstrating that the mammalian circadian clock is composed of an interconnected positive and negative transcriptional translational feedback loop (reviewed in Takahashi et al. 2008).
The mouse has proven to be a useful model system for the exploration of the genetics of diabetes and has a role to play in translating the results of GWAS (loci that contain genes that are relevant to human disease susceptibility), alongside other approaches.
Nevertheless, modeling a complex, multigenic disease like psoriasis in mice has proven to be extremely challenging and is associated with significant limitations.
Genome-wide haplotype association in inbred strains of mice has proven to be a useful experimental strategy to detect loci that regulate complex traits [37], [38].
The use of dense SNP maps in laboratory inbred mice has proven successful in the refinement of previous QTL regions and the identification of new genetic determinants of complex traits [4] [8].
The use of mice has proven useful to further our understanding of the events leading up to parturition owing to the ease with which the mouse genome can be manipulated.
The use of T-cell receptor transgenic (TCR-tg) mice has proven a powerful tool for investigating the nature of self-reactive T cells in tolerance and autoimmunity [ 3].
Published: May 15 , 2008Retroviral insertional mutagenesis in mice has proven to be an efficient tool for identification of novel cancer genes, providing a valuable complement to the study of human tumors.
