The number of foot processes of the podocytes did not differ between the mouse groups, indicating that the foot process effacement of the podocytes was affected to a similar degree in both mouse groups.
Conversely, the proportion of macrophages in the lungs was significantly lower in the 4-month-old MRL/ lpr mice than in the other two mouse groups, indicating that the increase of these infiltrating T cells may be responsible for the low number of macrophages in lung.
It was surprising that the percentage of DB treated mice with lung metastases was 60%, and not significantly different from the occurrence of lung metastases in the untreated mouse group, indicating the bicarbonate monotherapy as a more favorable treatment modality at least in this tumor model.
More importantly, a significant reduction in the number of bacteria recovered from the lungs was observed in mice immunized with CTB-Fim2 compared to those immunized with rFim2 or the control mice groups indicating that some antigen can offer protection when fused to CTB.
The data obtained from six mice per group, indicates that the weight-loss response is attenuated in the ILK-ko mice.
In contrast, plasma insulin levels did not increase significantly after licking for the fructose solution in either mouse group, as indicated by nonsignificant main effects of time (F1,11 = 3.1, P > 0.11) and mouse group (F1,11 < 0.1, P > 0.88) and a nonsignificant interaction of time × mouse group (F1,11 < 0.91, P > 0.47).
Pathological examination of the major organs of the mice in the diseased groups indicated an increase of Kupffer cells in the liver, loss of structural integrity in the lungs, and diffusion of white pulp in the spleen.
Furthermore, blood chemistry was normal in mice in all the treatment groups indicating no damage to the kidneys or livers.
Analysis of Stra8 in ovaries of YF mice from the three parabiotic pair groups indicated that expression of the gene was barely, if at all, detectable after joining with YF mice; however, increased expressed of Stra8 was detected in ovaries of YF mice paired with either YM or AM mice, and the magnitude of this response was age-dependent.
The swim speed in quadrants was comparable among the groups, indicating that the mice were not impaired in motility and exploratory behavior.
