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H&E-stained images from lungs of the corresponding mouse groups are shown in the bottom left panels.
These results suggest that most mouse groups are characterized by numerous DNA copy number changes, many of which are specific to a given model/group (Supplemental Table 4).
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Blood samples from all treated and control mouse groups were collected and centrifuged to obtain plasma samples.
Both mouse groups were carefully controlled for anatomical and physiological parameters relevant for edema formation and stroke outcome.
All mouse groups were sacrificed on day 40.
The mouse groups were kept under observation for 3 weeks after the drug treatment.
Mouse groups were rigorously age- and sex-matched for each infection experiment.
ABR thresholds in the three mouse groups were tested at 3, 4, 6, and 8 weeks of age.
For chronic drug experiments, mouse groups were sex-matched, with 40% to 60% of each sex in different cohorts.
Retinal pericytes in the various mouse groups were assessed using the trypsin digest technique as previously described [ 18].
For the in vivo oncolysis study, 10 mice were included in each treatment group, and the four mouse groups were treated as described above for two weeks.
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