Sentence examples for mouse germline such from inspiring English sources
The orthologues of the factors essential for paternal imprinting establishment in the mouse germline, such as DNMT3A, DNMT3L and BORIS/CTCFL, are also present in marsupials [ 48, 49].
The mouse germline is an excellent model for such studies.
Such compensation is suggested by our studies with genetic knockout of ADA3: deletion of ADA3 in mouse germline induces early embryonic lethality and its conditional deletion in mouse embryonic fibroblasts induces cell cycle block [ 24].
Introducing dominant oncogenic alterations uncovered in human myeloid malignancies into the mouse germline provides a powerful approach for studying leukemogenesis.
Engineering cancer-associated mutations into the mouse germline is an important tool for biological studies of growth control and tumorigenesis.
The ability to manipulate the mouse germline affords numerous approaches toward understanding the complexities of this disease, possibly providing accurate preclinical models for therapeutic and diagnostic advances.
One such element is the Sleeping Beauty (SB) transposon that has been shown in several studies to be an effective insertional mutagen in the mouse germline.
We found that hPGCs acquire a transcriptional program that is distinct from the mouse germline.
Third, the mouse germline can be easily manipulated to induce overexpression or knockout of target genes.
Neonatal and adult mouse germline stem cell lines were established after immunomagnetic isolation.
We therefore inactivated both Ltbp-4 isoforms in the mouse germline to model ARCL1C.
