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The action plan for mouse genomics was published in Nature Genetics [ 31].
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Finally, the impact of this technology to such diverse fields as bacterial pathogenesis, metabolic engineering, and mouse genomics is discussed.
In 2004 the Mary Lyon Centre, which is a national facility for mouse functional genomics, was opened in order to generate mouse models of human diseases.
The mouse genome is so important for human genomics that Celera switched its DNA sequencing machines from human to mouse at a point last year when it had barely gathered enough human DNA for its assembly program.
Celera Genomics, of Rockville, Maryland, has already sequenced a draft mouse genome, but it is available only to customers paying some $15,000 per year.The mouse genome is useful because of its similarity to the human genome.
To check whether specific regions of the mouse genome were protected from DNase digestion we mapped the mouse reads to the mouse genome and visualized their location using the Integrative Genomics Viewer software (Vers. 2.3.34) [ 34].
Comparative genomics was used to check the smallest congenic fragment for synthenic human and mouse regions with Ensembl release 53.
About 9,700 mouse genes (Incyte Genomics) were precisely spotted onto a single glass slide.
So Celera Genomics was formed.
A companion program, the Comparative Mouse Genomics Centers Consortium, was initiated by the EGP to develop transgenic and knockout mouse models based on human DNA sequence variants in environmentally responsive genes.
ES cell lines with insertions in the Lrsam1 gene generated by Bay Genomics were ordered from the Mouse Mutant Regional Resource Center MMRRCC).
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