However, bioinformatics analyses of human and mouse genomes indicate a substantial impact of TEs on cellular gene regulation; as many as 25% of genes possess TEs in their UTRs [8], [48].
Analysis of human and mouse genomes indicated that β-defensins form 4 5 distinct clusters on different chromosomes with each cluster consisting of multiple defensin genes [ 12].
Analyses of sequences across human, chimpanzee and mouse genomes indicate that one of the most divergent functional categories includes the genes involved in reproduction [ 32].
Analyses of human and mouse genomes indicated that TEs are significantly enriched in rapidly-evolving gene classes, such as those involved in immunity and response to external stimuli but are excluded from mRNAs of highly conserved genes with basic housekeeping functions in development, transcription, replication, cell structure and metabolism [ 12, 13].
Bioinformatic analysis showed that miR-141 and -200c are encoded within 500 bp in the mouse genome, indicating that they are generated from the same pri-miRNA.
Our initial experiments with human genome compression with respect to a mouse genome indicate that the matches are usually very short and the advantages of referential compression are mitigated.
However, ATTGG + CCAAT and AGATA + TATCT are underrepresented only in a half portion of the mouse genome, indicating that the biological function of these two pentanucleotides may differ from that for human.
Strikingly, variant complex-dependent PRC2 recruitment and H3K27me3 was also observed at a single naturally occurring TetO site in the mouse genome, indicating that this is not unique to the engineered TetO array.
Comparison of our Psg locus map with the public mouse genome database indicates good agreement in overall structure and further elucidates gene order.
Mouse genome (GRCm38/mm10) indicates Mus musculus genome assembled by the Genome Reference Consortium (GRCm38), UCSC version 10. tRFs, especially the tRF-5 series, are the second most abundant after microRNAs (Table 1).
