Analysis of human and mouse genomes indicated that β-defensins form 4 5 distinct clusters on different chromosomes with each cluster consisting of multiple defensin genes [ 12].
Evidence from the human and mouse genomes indicates that, in addition to providing the source of the transpositional machinery, transposable elements (or TEs) [ 4] can also provide the template DNA for new genes or regulatory sequences [ 5- 11].
Analyses of human and mouse genomes indicated that TEs are significantly enriched in rapidly-evolving gene classes, such as those involved in immunity and response to external stimuli but are excluded from mRNAs of highly conserved genes with basic housekeeping functions in development, transcription, replication, cell structure and metabolism [ 12, 13].
Our initial experiments with human genome compression with respect to a mouse genome indicate that the matches are usually very short and the advantages of referential compression are mitigated.
Bioinformatic analysis showed that miR-141 and -200c are encoded within 500 bp in the mouse genome, indicating that they are generated from the same pri-miRNA.
However, ATTGG + CCAAT and AGATA + TATCT are underrepresented only in a half portion of the mouse genome, indicating that the biological function of these two pentanucleotides may differ from that for human.
Strikingly, variant complex-dependent PRC2 recruitment and H3K27me3 was also observed at a single naturally occurring TetO site in the mouse genome, indicating that this is not unique to the engineered TetO array.
In addition, formation of CGs is not only limited to human, as we have also identified unique CGs in, among others, the mouse and drosophila genomes, indicating towards their functional relevance.
A search of the mouse genome database indicated that CSRNP-1 is a member of a family of three related proteins.
